Curie Bioinformatics Server

B-cell Epitope Prediction
Server (BCEP)

Prediction of B-cell epitopes using antigen 3D structure alone — no phage display data required.

Submit a Structure

Prediction of B-cell epitopes using antigen 3D structure. For prediction, please use a monomer structure, select patch size and solvent accessible surface area threshold. You can use a standard PDB ID or one word for your PDB file name.

Help: Please do not upload a protein complex — use only one chain. For patch sizes from 8Å to 15Å, the default patch score threshold is 95.0. All results are printed based on the top X% of the highest patch score on the antigen surface. For errors, contact [email protected].

Input guidelines

  • Monomer only. Do not upload a protein complex.
  • Use a single-chain monomeric PDB file.
  • Use a simple filename, e.g. ABCD123456XYZ.pdb
  • Patch size range: 8Å – 15Å. Default score threshold: 95.0.
  • Results reflect the top scoring patches on the antigen surface.
Structure preview
B-cell epitope structure preview

Example input

Example input from B-cell Epitope Prediction Server
Example input from BCEP

Example output

Example output from B-cell Epitope Prediction Server
Example output from BCEP

Disclaimer

This service is provided freely to the scientific community for the purpose of scientific research. There is no warranty for the service, either expressed or implied. The entire risk as to the quality and performance of the service is with the user. In no event will the Sealy Center for Structural Biology be liable for any damages, including any general, special, or consequential damages arising out of the use, misuse, or inability to use this service.